Partnering for the major histocompatibility complex class II and antigenic determinant requires flexibility and chaperons

S Sadegh-Nasseri - Current opinion in immunology, 2021 - Elsevier
bind peptides stably but non-specifically! The solution of the MHC class II crystal structure, …
The CLIP region was shown to binds to the groove of MHC II molecules in the endoplasmic …

[HTML][HTML] Superantigen recognition and interactions: functions, mechanisms and applications

AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
… The results showed that the optimal number of immunoglobulin binding domains to
induce the largest B-cell response was 5 (95). This observation suggests that B-cell …

[PDF][PDF] Influence of the NH2-terminal Amino Acid of the T Cell Receptor ɑ Chain on Major Histocompatibility Complex (MHC) Class II+ Peptide Recognition

JL Seibel, N Wilson, H Kozono, P Marrack, JW Kappler - academia.edu
… with solutions of various soluble TCR s at 5 μg/ ml until binding to … in the ɑ helical region of
the MHC class I ɑ1 domain (14). … The Vß-specific superantigen Staphylococcal enterotoxin B: …

[PDF][PDF] … OF FIVE MONOCLONAL ANTIBODIES SPECIFIIC FOR SWINE CLASS II MAJOR HISTOCOMPATIBILITY ANTIGENS AND CROSSREACTIVITY STUDIES …

R ESullido, N Domknech, B Alvarez, F Afonso, M Babin… - academia.edu
… the addition of 5 mL of 10 mM solution of EDTA in phosphate … class II molecules in a region
outside of the peptide bindingSuperantigens interact with MHC class II molecules outside …

Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding

S Rahman, S Saha, SB Dasgupta, AK Das - International Journal of …, 2024 - Elsevier
… , important residues that are vital for the T-cell receptor (TcR) and major histocompatibility
complex class II (MHC-II… antigen binding domain, whether our predicted superantigen can also …

[HTML][HTML] Blocking Superantigen-Mediated Diseases: Challenges and Future Trends

P Wang, Z Fredj, H Zhang, G Rong, S Bian… - Journal of Immunology …, 2024 - hindawi.com
… to bind major histocompatibility complex class II molecules … , Groups II and III SAgs have
an α- and β-chain binding regionbinding)-fold: common structural and functional solution for …

Specific T cells targeting Staphylococcus aureus fibronectin‐binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients

AK Farag, LM Roesner, S Wieschowski… - Allergy, 2022 - Wiley Online Library
… from different functional domains of the FBP1 sequence. … superantigen capacities. We identified
earlier fibronectin-… synthesis of MHC (major histocompatibility complex) class II tetramers. …

A general platform for targeting MHC-II antigens via a single loop

H Du, J Liu, KM Jude, X Yang, Y Li, B Bell, H Yang… - bioRxiv, 2024 - biorxiv.org
… interactions between major histocompatibility complexes (MHCs… on the ARE region that are
closest to MHC-II-bound peptide … the unique binding features of the superantigen MAM could …

The zinc ions stabilize the three-dimensional structure and are required for the binding of staphylococcal enterotoxin-like protein P (SEIP) with MHC-II receptors

I Shulcheva, M Shchannikova, B Melnik… - Protein Expression and …, 2022 - Elsevier
histocompatibility complex class II (MHCII) and T-cell receptor (… The superantigenic activity
of staphylococcal enterotoxins … with the class two major histocompatibility antigens (MHC-II) …

[HTML][HTML] Streptococcus pyogenes Superantigens: Biological properties and potential role in disease

T Proft, JD Fraser - … Biology to Clinical Manifestations [Internet]. 2nd …, 2022 - ncbi.nlm.nih.gov
bind as unprocessed molecules to major histocompatibility (… bind to major histocompatibility
complex (MHC) class II on … , but absence of a generic MHC class II α-chain binding region